Novel Therapy for Unresectable Hilar Cholangiocarcinoma ‘Klatskin Tumor’ Utilizing Percutaneous Irreversible Electroporation: A Case Report

Cholangiocarcinoma is the 2nd most common primary hepatic malignancy with an incidence in the United States ranging from 0.40.9/100,000 with 5 year survival estimated at 2.6-4.4% [1]. The average age at diagnosis of cholangiocarcinoma is 50 years old with curative options including surgical resection, neoadjuvant chemoradiation, and liver transplantation [2]. Staging is based on anatomic location in accordance with Bismuth–Corlette staging classification used for perihilar tumors. Given most tumors, remain asymptomatic until later stages surgical resection is often unavailable which further decreases prognosis. For unresectable tumors, treatment is limited to chemoradiation and stenting for palliation of obstructive symptoms. Given these limitations, alternative treatment options and therapies need to be considered.